Antimicrobial activity of Lactobacillus acidophilus bacteriocin against clinical isolates

Lactic acid bacteria serve as important human probiotics, they can produce bacteriocins from different dairy sources, and the antimicrobial activity of their have been documented in scientific field. This study aimed to assess activities bacteriocin obtained sources. An experimental analytical design was used isolate species on de Man, Rogosa Sharpe Media, identify them phenotypically evaluated bacteriocin's against four clinical isolates. SPSS Version 22 for Statistical purposes. A total 14 isolates were verified various sample These included 6 camel's milk, 2 goat's 3 local yogurt, Omani yogurt. The supernatants most exhibited varying levels during investigation. Furthermore, action concentration dependent. highest level inhibition mm Staphylococcus aureus, 12 for, 10 when using 100μl raw bacteriocin. Moreover, correlation between activity, temperatures, incubation times found be irreversible. reveals inherent antibacterial traits milk products Al-Shihr Town. Specifically, variant, synthesizing bacteriocin, effectively suppressed isolates, showcasing pathogen-fighting ability. findings offer potential developing efficient methods, utilizing an antibiotic food medicine.